Technician ALS Research Job at UMC Utrecht | EURES

An exciting position as a laboratory technician within the ALS Center and the iPSC facility of the Department of Translational Neuroscience. The focus of this role is to establish and further develop cell models to study disease mechanisms and novel gene-targeted therapies for ALS.

• Establish and further develop cell models to study disease mechanisms and novel gene-targeted therapies for ALS
• Develop a diverse set of skills, including the transdifferentiation of fibroblasts and PBMCs into neurons (iNeurons)
• Screening of antisense oligonucleotides (AONs)
• Characterization of treatment response through live-cell imaging, staining, and possibly electrophysiological studies or transcriptomic analyses
• Actively contribute to further improve existing models

• Laboratory technician skills
• Cell model development
• Transdifferentiation of fibroblasts and PBMCs into neurons
• Screening of antisense oligonucleotides
• Live-cell imaging
• Staining
• Electrophysiological studies (possibly)
• Transcriptomic analyses (possibly)